| BlackRock, Inc. | 5,172,063 | $18.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 4,442,951 | $15.6m | 0.0% |
| ARMISTICE CAPITAL, LLC | 3,436,000 | $12.0m | 0.1% |
| Vestal Point Capital, LP | 2,625,000 | $9.2m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,345,674 | $8.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,330,492 | $4.7m | 0.0% |
| Opaleye Management Inc. | 1,185,000 | $4.1m | 0.4% |
| STATE STREET CORP | 1,076,422 | $3.8m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 948,517 | $3.3m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 838,184 | $2.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 810,091 | $2.8m | 0.0% |
| CITADEL ADVISORS LLC | 784,067 | $2.7m | 0.0% |
| MORGAN STANLEY | 697,334 | $2.4m | 0.0% |
| Erste Asset Management GmbH | 638,900 | $2.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 495,236 | $1.7m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 427,554 | $1.5m | 0.2% |
| ACADIAN ASSET MANAGEMENT LLC | 428,670 | $1.5m | 0.0% |
| DIADEMA PARTNERS LP | 413,642 | $1.4m | 0.2% |
| NORTHERN TRUST CORP | 411,803 | $1.4m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 356,109 | $1.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 338,477 | $1.2m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 337,325 | $1.2m | 0.0% |
| Fiduciary Trust Co | 334,397 | $1.2m | 0.0% |
| JPMORGAN CHASE & CO | 276,211 | $988,836 | 0.0% |
| Point72 Asset Management, L.P. | 236,083 | $826,291 | 0.0% |