| Corvex Management LP | 4,784,570 | $328.5m | 10.0% |
| Casdin Capital, LLC | 3,707,164 | $254.5m | 12.7% |
| BlackRock, Inc. | 1,706,239 | $117.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,669,441 | $114.6m | 0.0% |
| ARK Investment Management LLC | 1,610,189 | $110.5m | 0.7% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,400,653 | $96.2m | 0.3% |
| MORGAN STANLEY | 988,297 | $67.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 879,003 | $60.3m | 0.0% |
| CITADEL ADVISORS LLC | 865,462 | $59.4m | 0.0% |
| First Light Asset Management, LLC | 783,923 | $53.8m | 3.3% |
| Deep Track Capital, LP | 700,000 | $48.1m | 0.7% |
| Sumitomo Mitsui Trust Group, Inc. | 666,581 | $45.8m | 0.0% |
| Amova Asset Management Americas, Inc. | 666,581 | $45.7m | 0.6% |
| Assenagon Asset Management S.A. | 606,866 | $41.7m | 0.0% |
| Zweig-DiMenna Associates LLC | 571,950 | $39.3m | 3.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 552,125 | $37.9m | 0.0% |
| STATE STREET CORP | 527,815 | $36.2m | 0.0% |
| GAGNON SECURITIES LLC | 524,865 | $36.0m | 6.9% |
| Aberdeen Group plc | 457,201 | $31.4m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 347,927 | $23.9m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 346,211 | $23.8m | 0.0% |
| FRANKLIN RESOURCES INC | 280,938 | $19.3m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 280,619 | $19.3m | 0.0% |
| NORGES BANK | 273,100 | $18.7m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 269,542 | $18.5m | 0.2% |