| Yu Fan | 4,861,314 | $22.3m | 20.6% |
| ACUTA CAPITAL PARTNERS, LLC | 4,685,912 | $21.5m | 15.0% |
| QVT Financial LP | 4,615,709 | $21.1m | 1.2% |
| MONTANOVA CAPITAL, LLC | 4,300,000 | $19.7m | 0.4% |
| ORBIMED ADVISORS LLC | 3,934,296 | $18.0m | 0.3% |
| Avoro Capital Advisors LLC | 2,849,402 | $13.1m | 0.1% |
| Siren, L.L.C. | 2,337,102 | $10.7m | 0.2% |
| KVP Capital Advisors, LP | 2,165,997 | $9.9m | 7.3% |
| BlackRock, Inc. | 1,922,828 | $8.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,388,561 | $6.4m | 0.0% |
| ADAR1 Capital Management, LLC | 1,341,394 | $6.1m | 0.3% |
| ACORN CAPITAL ADVISORS, LLC | 1,139,363 | $5.2m | 1.4% |
| STEMPOINT CAPITAL LP | 1,021,037 | $4.7m | 0.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 899,780 | $4.1m | 0.0% |
| Ally Bridge Group (NY) LLC | 817,939 | $3.7m | 3.3% |
| Woodline Partners LP | 436,614 | $2.0m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 413,822 | $1.9m | 0.0% |
| STATE STREET CORP | 386,982 | $1.8m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 380,406 | $1.7m | 0.0% |
| Eversept Partners, LP | 303,306 | $1.4m | 0.1% |
| Verdad Advisers, LP | 301,483 | $1.4m | 1.3% |
| TWO SIGMA INVESTMENTS, LP | 296,612 | $1.4m | 0.0% |
| Balyasny Asset Management L.P. | 288,117 | $1.3m | 0.0% |
| NORTHERN TRUST CORP | 264,689 | $1.2m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 246,907 | $1.1m | 0.0% |