| FMR LLC | 9,647,998 | $582.4m | 0.0% |
| BlackRock, Inc. | 7,522,482 | $454.1m | 0.0% |
| Avoro Capital Advisors LLC | 5,777,777 | $348.7m | 3.1% |
| Polar Capital Holdings Plc | 4,570,556 | $275.9m | 0.7% |
| Driehaus Capital Management LLC | 4,418,557 | $266.7m | 1.5% |
| Jupiter Topco LLC | 4,186,519 | $252.7m | 0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,248,219 | $196.1m | 0.0% |
| JPMORGAN CHASE & CO | 2,617,360 | $157.4m | 0.0% |
| Capital International Investors | 2,361,639 | $142.5m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 2,168,581 | $130.9m | 0.1% |
| STATE STREET CORP | 1,969,629 | $118.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,642,848 | $99.2m | 0.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,615,696 | $97.5m | 1.0% |
| Affinity Asset Advisors, LLC | 1,595,000 | $96.3m | 4.4% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,507,294 | $91.0m | 0.3% |
| ALLIANCEBERNSTEIN L.P. | 1,562,276 | $90.8m | 0.0% |
| FRANKLIN RESOURCES INC | 1,437,712 | $86.8m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,425,492 | $86.0m | 0.0% |
| CITADEL ADVISORS LLC | 1,401,242 | $84.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,370,114 | $82.7m | 0.0% |
| Siren, L.L.C. | 1,318,564 | $79.6m | 1.6% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,290,731 | $77.9m | 0.1% |
| Pictet Asset Management Holding SA | 1,187,723 | $71.6m | 0.1% |
| BRAIDWELL LP | 1,131,452 | $68.3m | 2.5% |
| Nuveen, LLC | 993,126 | $59.9m | 0.0% |